TY  - JOUR
PY  - 2020//
TI  - The rs6265 polymorphism of the BDNF gene is related to higher-lethality suicide attempts in the Korean population
JO  - Psychiatry investigation
A1  - Kang, Seung-Gul
A1  - Lee, Jong Hun
A1  - Lee, Kwanghun
A1  - Kim, Hee-Cheol
A1  - Seo, Wan Seok
A1  - Won, Seunghee
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVE: Since the risk of suicide cannot be predicted by clinical symptoms alone, and suicide is known to have a genetic component, the discovery of genetic markers that can predict the lethality of suicide attempts is a clinically important topic. There have been many studies aiming to determine whether the rs6265 polymorphism of the BDNF gene is associated with suicidality; however, the results have been mixed, and there have been few studies investigating the relationship between this polymorphism and suicide attempt lethality. <br><br>METHODS: We assessed suicide lethality in 258 individuals who had attempted suicide using the relative risk ratio (RRR) scale and by genotyping the rs6265 polymorphism of the BDNF gene. <br><br>RESULTS: The RRR score for suicide attempts was higher in subjects with Met/Val and Val/Val genotypes than in that with a Met/Met genotype (p=0.015). The RRR score for suicide attempts was also higher in Val allele carriers (Met/Val+Val/Val) than in Met/Met homozygotes (p=0.006). <br><br>CONCLUSION: This study demonstrates the possibility that the rs6265 polymorphism of the BDNF gene could be used as a genetic marker to predict the lethality of suicide attempts, but more replication studies are needed for the application of this result in clinical practice.<p />  <p>Language: en</p>
LA  - en
SN  - 1738-3684
UR  - http://dx.doi.org/10.30773/pi.2020.0012
ID  - ref1
ER  -