TY  - JOUR
PY  - 2020//
TI  - Clinical and neuroendocrine correlates of childhood maltreatment history in adults with bipolar disorder
JO  - Bipolar disorders
A1  - Monteleone, Alessio Maria
A1  - Cascino, Giammarco
A1  - Marciello, Francesca
A1  - D'Agostino, Giulia
A1  - Caivano, Vito
A1  - Monteleone, Palmiero
A1  - Maj, Mario
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVES: Childhood maltreatment has been associated to an increased risk of developing bipolar disorder (BD). A role of the hypothalamus-pituitary-adrenal (HPA) axis in mediating the trauma-related risk for adult psychopathology has been suggested but scarcely investigated in BD. Therefore, we explored the impact of childhood maltreatment on clinical features of BD and on the activity of the HPA axis. <br><br>METHODS: One-hundred-six patients participated into the study. On the basis of their history of childhood trauma, as assessed by the Childhood Trauma Questionnaire (CTQ), they were divided in a group with history of childhood maltreatment (CM+) and a group without (CM-). Twenty-nine participants (16 with history of childhood trauma and 13 without) underwent the cortisol awakening response (CAR) test. <br><br>RESULTS: Sixty-two patients had a history of childhood maltreatment and 44 had not. Maltreatment was significantly more frequent in females than males. CM+ patients showed a significant higher body mass index, a significant higher number of suicide attempts and more severe mania symptoms than CM- ones. Logistic regression indicated a significant association between lifetime suicide attempts and any type of childhood maltreatment and between emotional abuse and the presence of psychotic symptoms or mixed mood episodes. CM+ individuals with BD exhibited a significantly reduced CAR with respect to CM- ones. <br><br>DISCUSSION: Our results add to literature findings showing a worse clinical course in BD patients with a history of childhood maltreatments and show for the first time that childhood trauma exposure is associated to an impaired CAR in adults with BD.<br><br>This article is protected by copyright. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 1398-5647
UR  - http://dx.doi.org/10.1111/bdi.12923
ID  - ref1
ER  -