TY  - JOUR
PY  - 2020//
TI  - Delayed prefrontal hemodynamic response associated with suicide risk in autism spectrum disorder
JO  - Psychiatry research
A1  - Ota, Toyosaku
A1  - Iida, Junzo
A1  - Okazaki, Kosuke
A1  - Ishida, Rio
A1  - Takahashi, Masato
A1  - Okamura, Kazuya
A1  - Yamamuro, Kazuhiko
A1  - Kishimoto, Naoko
A1  - Kimoto, Sohei
A1  - Yasuda, Yuka
A1  - Hashimoto, Ryota
A1  - Makinodan, Manabu
A1  - Kishimoto, Toshifumi
SP  - e112971
EP  - e112971
VL  - 289
IS  - 
N2  - Adults diagnosed with Autism spectrum disorder (ASD) are at high risk of experiencing suicidality compared with other clinical groups. Recently, near-infrared spectroscopy (NIRS) studies have investigated the association between frontotemporal functional abnormalities and suicidality in patients with mood disorders. However, whether these prefrontal hemodynamic responses are associated with suicide vulnerability in individuals with ASD remains unclear. Here, we used 24-channel NIRS to examine the characteristics of prefrontal hemodynamic responses during a verbal fluency task in 20 adults with ASD and in age-, sex-, and intelligence quotient-matched healthy controls. In addition, we used Spearman's correlation analysis to identify the relationship between the time-course of prefrontal hemodynamic activation and the current suicide risk in patients with ASD. We found no significant differences between the verbal fluency task-induced prefrontal hemodynamic responses in the ASD vs. control group. However, we found a significant positive correlation between the current suicide risk score and the time-course of prefrontal hemodynamic activation in the ASD group. Thus, the 24-channel NIRS system appears to be useful in assessing suicide risk in individuals with ASD.<br><br>Copyright © 2020 Elsevier B.V. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/10.1016/j.psychres.2020.112971
ID  - ref1
ER  -