TY  - JOUR
PY  - 2020//
TI  - Effects of blast wave-induced biomechanical changes on lung injury in rats
JO  - Biomedical and environmental sciences
A1  - Liu, Wei
A1  - Chai, Jia Ke
A1  - Qin, Bin
A1  - Han, Shao Fang
A1  - Wang, Xiao Teng
A1  - Jiang, Shuai
A1  - Bai, Hai Liang
A1  - Liu, Ling Ying
A1  - Chang, Yang
A1  - Yue, Xiao Tong
A1  - Wu, Yu Shou
A1  - Zhang, Zi Hao
A1  - Tang, Lang
SP  - 338
EP  - 349
VL  - 33
IS  - 5
N2  - OBJECTIVE: To observe the dynamic impacts of shock waves on the severity of lung injury in rats with different injury distances. <br><br>METHODS: Simulate open-field shock waves; detect the biomechanical effects of explosion sources at distances of 40, 44, and 48 cm from rats; and examine the changes in the gross anatomy of the lungs, lung wet/dry weight ratio, hemoglobin concentration, blood gas analysis, and pathology. <br><br>RESULTS: Biomechanical parameters such as the overpressure peak and impulse were gradually attenuated with an increase in the injury distance. The lung tissue hemorrhage, edema, oxygenation index, and pathology changed more significantly for the 40 cm group than for the 44 and 48 cm groups. The overpressure peak and impulse were significantly higher for the 40 cm group than for the 44 and 48 cm groups ( <i>P</i> < 0.05 or <i>P</i> < 0.01). The animal mortality was significantly higher for the 40 cm group than for the other two groups (41.2% <i>vs</i>. 17.8% and 10.0%, <i>P</i> < 0.05). The healing time of injured lung tissues for the 40 cm group was longer than those for the 44 and 48 cm groups. <br><br>CONCLUSIONS: The effects of simulated open-field shock waves on the severity of lung injuries in rats were correlated with the injury distances, the peak overpressure, and the overpressure impulse.<br><br>Copyright © 2020 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0895-3988
UR  - http://dx.doi.org/10.3967/bes2020.046
ID  - ref1
ER  -