TY  - JOUR
PY  - 2020//
TI  - Vitamin D megadose: definition, efficacy in bone metabolism, risk of falls and fractures
JO  - Open access rheumatology : research and reviews
A1  - Narvaez, Jemina
A1  - Maldonado, Genessis
A1  - Guerrero, Roberto
A1  - Messina, Osvaldo Daniel
A1  - Rios, Carlos
SP  - 105
EP  - 115
VL  - 12
IS  - 
N2  - INTRODUCTION: Currently, approximately more than one billion people around the world are considered to have deficient levels of vitamin D. International consensus recommends vitamin D supplementation to high-risk patients (advanced age, osteoporosis, liver failure, malabsorption syndromes, etc.) and those with levels below 30 ng/mL. There are several vitamin D formulations and dosages available, including megadoses. At the moment, there is no consensus on the definition of megadoses.     The purpose of this review is to define what is a megadose and analyze its effectiveness in bone metabolism, risk of fractures and falls.     Conclusion: The administration of doses higher than 100,000 IU of vitamin D is considered a megadose. It is evident that the use of megadoses increases serum concentrations of vitamin D; however, there has been no evidence of a decrease in the risk of falls, vertebral fractures or changes in bone mineral density.<p />  <p>Language: en</p>
LA  - en
SN  - 1179-156X
UR  - http://dx.doi.org/10.2147/OARRR.S252245
ID  - ref1
ER  -