TY  - JOUR
PY  - 2020//
TI  - Comorbid anxiety and suicidal behaviors in American adolescents with major depression
JO  - Curēus
A1  - Mathialagan, Keerthika
A1  - Ceren Amuk, Ozge
A1  - Eskander, Noha
A1  - Patel, Rikinkumar S.
SP  - e8598
EP  - e8598
VL  - 12
IS  - 6
N2  - OBJECTIVE The aim of this study was to evaluate the odds of association between suicidal behaviors and comorbid anxiety disorders in adolescents with major depressive disorder (MDD). <br><br>METHODS We included 122,020 adolescent inpatients with MDD from the Nationwide Inpatient Sample (NIS) and further grouped them by co-diagnosis of anxiety disorders. Logistic regression analysis was used to evaluate the odds ratio (OR) of suicidal behaviors due to comorbid anxiety disorders. <br><br>RESULTS Out of total MDD inpatients, 45.8% had comorbid anxiety disorders. Around 53.5% MDD inpatients with anxiety disorders had suicidal behaviors, which were significantly higher than seen in 52.6% non-anxiety cohort (P = 0.002). Comorbid anxiety disorders had a minimally positive association with suicidal behaviors and were not statistically significant (OR: 1.01; P = 0.710) after controlling the logistic regression analysis for demographic confounders and psychiatric comorbidities. MDD inpatients with comorbid psychotic disorders were positively associated (OR: 1.16; P = 0.007) with suicidal behaviors. <br><br>CONCLUSIONS MDD with comorbid anxiety had a statistically non-significant association with suicidal behaviors in adolescents. Depression has a direct and independent effect on adolescent suicidal behaviors, whereas anxiety has a direct effect only on perpetuating depression. Early diagnosis and management of comorbid anxiety and psychosis with MDD reduce functional impairment and suicide risk in at-risk populations.<p />  <p>Language: en</p>
LA  - en
SN  - 2168-8184
UR  - http://dx.doi.org/10.7759/cureus.8598
ID  - ref1
ER  -