TY  - JOUR
PY  - 2020//
TI  - "Influence of modifiable and non-modifiable variables on functioning in bipolar disorder: a path analytical study"
JO  - International journal of psychiatry in clinical practice
A1  - Cotrena, Charles
A1  - Damiani Branco, Laura
A1  - Milman Shansis, Flávio
A1  - Paz Fonseca, Rochele
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVE: The aim of this study was to investigate the influence of modifiable (mood, cognitive reserve, cognitive performance) and non-modifiable factors (diagnosis, suicide attempts, substance use, age) on self-reported functioning in BD.     METHODS: 103 adults with no mood disorders and 95 individuals with BD completed the WHODAS 2.0, in addition to a neuropsychological battery and diagnostic assessments. Path analysis was then used to analyse the relationships between modifiable and non-modifiable predictors of functioning in the sample.     RESULTS: Cognitive reserve and age had an indirect influence on individual functioning, mediated by cognitive performance. The influence of diagnosis and depressive symptoms on functioning was partly direct, and partly mediated by cognition. The presence of psychiatric comorbidities in addition to BD also had a significant influence on individual functioning.     CONCLUSIONS: Initiatives focussed on modifiable factors such as depressive symptoms and cognitively stimulating activities, which increase cognitive reserve, may be a useful complement to existing treatments and help patients achieve functional recovery.     KEY POINTS Individual functioning was influenced by cognitive performance, cognitive reserve, age, diagnosis and depressive symptoms. Executive functioning mediated the influence of age and cognitive reserve on individual functioning. Interventions focussed on depressive symptoms and cognitive stimulation may help patients achieve functional recovery.<p />  <p>Language: en</p>
LA  - en
SN  - 1365-1501
UR  - http://dx.doi.org/10.1080/13651501.2020.1779307
ID  - ref1
ER  -