TY  - JOUR
PY  - 2020//
TI  - Effectiveness of internet- and mobile-based cognitive behavioral therapy to reduce suicidal ideation and behaviors: protocol for a systematic review and meta-analysis of individual participant data
JO  - International journal of environmental research and public health
A1  - Büscher, Rebekka
A1  - Beisemann, Marie
A1  - Doebler, Philipp
A1  - Steubl, Lena
A1  - Domhardt, Matthias
A1  - Cuijpers, Pim
A1  - Kerkhof, Ad
A1  - Sander, Lasse B.
SP  - e5179
EP  - e5179
VL  - 17
IS  - 14
N2  - Internet- and mobile-based cognitive behavioral therapy (iCBT) might reduce suicidal ideation. However, recent meta-analyses found small effect sizes, and it remains unclear whether specific subgroups of participants experience beneficial or harmful effects. This is the study protocol for an individual participant meta-analysis (IPD-MA) aiming to determine the effectiveness of iCBT on suicidal ideation and identify moderators. We will systematically search CENTRAL, PsycINFO, Embase, and Pubmed for randomized controlled trials examining guided or self-guided iCBT for suicidality. All types of control conditions are eligible. Participants experiencing suicidal ideation will be included irrespective of age, diagnoses, or co-interventions. We will conduct a one-stage IPD-MA with suicidal ideation as the primary outcome, using a continuous measure, reliable improvement and deterioration, and response rate. Moderator analyses will be performed on participant-, study-, and intervention-level. Two independent reviewers will assess risk of bias and the quality of evidence using Cochrane's Risk of Bias Tool 2 and GRADE. This review was registered with OSF and is currently in progress. The IPD-MA will provide effect estimates while considering covariates and will offer novel insights into differential effects on a participant level. This will help to develop more effective, safe, and tailored digital treatment options for suicidal individuals.<p />  <p>Language: en</p>
LA  - en
SN  - 1661-7827
UR  - http://dx.doi.org/10.3390/ijerph17145179
ID  - ref1
ER  -