TY  - JOUR
PY  - 2020//
TI  - Impact of number of drugs on rehabilitation outcomes in patients after traumatic brain injury: a retrospective cohort study
JO  - PM & R : the journal of injury, function, and rehabilitation
A1  - Yamaoka, Makiko
A1  - Chono, Masayuki
A1  - Fukumoto, Miki
A1  - Watanabe, Tomomi
A1  - Fukaya, Takeshi
A1  - Momosaki, Ryo
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVE: The aim of this study was to investigate the impact of the number of drugs on rehabilitation outcomes for patients with acute traumatic brain injury.     DESIGN: Retrospective cohort study.     SETTING: Hospital-based database created by the Japan Medical Data Center.     PARTICIPANTS: Patients with acute traumatic brain injuryadmittedbetween April 2014 and November 2017.     METHODS: Analysis of relationships among 1-5 and ≥6 drugs as well as clinical outcomes in 2603 patients.     MAIN OUTCOME MEASUREMENTS: The primary outcome was defined as the Barthel index efficiency, and the secondary outcome was Barthel index gain and length of hospital stay.     RESULTS: Median Barthel index score on admission was 40. Barthel index efficiency and Barthel index gain were significantly higher in the group that had taken 1-5 drugs than in the group that had taken ≥6 drugson admission (median: 1.19 vs 0.50, 20.0 vs 10.0). Also, the group that had taken 1-5 drugshad a significantly shorter length of hospital stay than in the group that had taken ≥6 drugson admission (median 11.0 vs 14.0). Moreover, multiple linear regression analysis showed that having taken ≥6 drugs on admission was independently associated with Barthel index efficiency, Barthel index gain, and length of stay.     CONCLUSIONS: Taking≥6 drugs for acute traumatic brain injury was associated with lower Barthel index efficiency,lower Barthel index gain, and longer length of stay than taking 1-5 drugs.<p />  <p>Language: en</p>
LA  - en
SN  - 1934-1482
UR  - http://dx.doi.org/10.1002/pmrj.12460
ID  - ref1
ER  -