TY  - JOUR
PY  - 2020//
TI  - Falls associate with neurodegenerative changes in ATN framework of Alzheimer's disease
JO  - Journal of Alzheimer's disease
A1  - Keleman, Audrey
A1  - Wisch, Julie K.
A1  - Bollinger, Rebecca M.
A1  - Grant, Elizabeth A.
A1  - Benzinger, Tammie L.
A1  - Morris, John C.
A1  - Ances, Beau M.
A1  - Stark, Susan L.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Behavioral markers for Alzheimer's disease (AD) are not included within the widely used amyloid-tau-neurodegeneration framework.     OBJECTIVE: To determine when falls occur among cognitively normal (CN) individuals with and without preclinical AD.     METHODS: This cross-sectional study recorded falls among CN participants (n = 83) over a 1-year period. Tailored calendar journals recorded falls. Biomarkers including amyloid positron emission tomography (PET) and structural and functional magnetic resonance imaging were acquired within 2 years of fall evaluations. CN participants were dichotomized by amyloid PET (using standard cutoffs). Differences in amyloid accumulation, global resting state functional connectivity (rs-fc) intra-network signature, and hippocampal volume were compared between individuals who did and did not fall using Wilcoxon rank sum tests. Among preclinical AD participants (amyloid-positive), the partial correlation between amyloid accumulation and global rs-fc intra-network signature was compared for those who did and did not fall.     RESULTS: Participants who fell had smaller hippocampal volumes (p = 0.04). Among preclinical AD participants, those who fell had a negative correlation between amyloid uptake and global rs-fc intra-network signature (R = -0.75, p = 0.012). A trend level positive correlation was observed between amyloid uptake and global rs-fc intra-network signature (R = 0.70, p = 0.081) for preclinical AD participants who did not fall.     CONCLUSION: Falls in CN older adults correlate with neurodegeneration biomarkers. Participants without falls had lower amyloid deposition and preserved global rs-fc intra-network signature. Falls most strongly correlated with presence of amyloid and loss of brain connectivity and occurred in later stages of preclinical AD.<p />  <p>Language: en</p>
LA  - en
SN  - 1387-2877
UR  - http://dx.doi.org/10.3233/JAD-200192
ID  - ref1
ER  -