TY  - JOUR
PY  - 2020//
TI  - Association between anxiolytic/hypnotic drugs and suicidal thoughts or behaviors in a population-based cohort of students
JO  - Psychiatry research
A1  - Lecat, Nicolas
A1  - Fourrier-Réglat, Annie
A1  - Montagni, Ilaria
A1  - Tzourio, Christophe
A1  - Pariente, Antoine
A1  - Verdoux, Helene
A1  - Tournier, Marie
SP  - e113276
EP  - e113276
VL  - 291
IS  - 
N2  - AIMS: To investigate the association between the use of anxiolytic/hypnotic drugs and suicidal thoughts and/or behavior (STB) in students.     METHODS: 12,112 participants who completed the baseline questionnaire in the i-Share cohort between April 2013 and March 2017 were included. STB were defined at inclusion as suicidal thoughts over the previous year and/or a lifetime suicide attempt. The use of prescribed anxiolytic/hypnotic drugs over the previous 3 months was measured at baseline and follow-up time points (in 2,919 students). Psychiatric disorders were assessed through validated scales. Multivariate logistic regression models were run using disease risk score.     RESULTS: At inclusion, 25.2% of students had STB and 10.3% used anxiolytics/hypnotics. STB at baseline were associated with a more frequent use of anxiolytics/hypnotics in the previous 3 months, after adjustment for covariates including anxiety, depression, sleep, impulsivity, and substance use. The use of anxiolytics/hypnotics at baseline was not associated with the occurrence, persistence or remission of STB one year later. STB at baseline were associated with a new anxiolytic/hypnotic treatment one year later.     CONCLUSIONS: Anxiolytic/hypnotic drug use was associated with STB in students independently of many risk factors of suicide and most psychiatric disorders that require such treatment, which raises drug safety concerns.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/10.1016/j.psychres.2020.113276
ID  - ref1
ER  -