TY  - JOUR
PY  - 2020//
TI  - Adverse reactions after administration of antivenom in Korea
JO  - Toxins (Basel)
A1  - Shim, Jin Seok
A1  - Kang, Hyunggoo
A1  - Cho, Yongil
A1  - Shin, Hyungoo
A1  - Lee, Heekyung
SP  - e507
EP  - e507
VL  - 12
IS  - 8
N2  - Kovax® antivenom is the main treatment for toxins produced by the Gloydius species. However, research on adverse reactions after Kovax® antivenom administration is scarce. We aimed to identify the incidence and characteristics of adverse reactions after Kovax® antivenom administration. We conducted a retrospective review of the medical records of snakebite patients in Korea between January 2008 and September 2019. We identified the frequency, characteristics, and treatments of adverse reactions to Kovax® antivenom. There were 150 patients with snakebites, of whom 121 (80.7%) patients received Kovax® antivenom. Adverse reactions occurred in five patients (4.1%). Acute adverse reactions within 24 h of antivenom administration occurred in two patients (1.7%). The symptoms of patients with acute adverse reactions were nausea, diaphoresis, dizziness, and hypotension. Delayed adverse reactions that occurred 24 h after antivenom administration were reported in three patients (2.5%). One patient had a skin rash after 10 days, and two patients had fever 37 and 48 h after antivenom use. In conclusion, most patients were managed safely after Kovax® antivenom, and the incidence of adverse reactions was low. Severe adverse reactions occurred in a small percentage of patients, and there were no deaths.<p />  <p>Language: en</p>
LA  - en
SN  - 2072-6651
UR  - http://dx.doi.org/10.3390/toxins12080507
ID  - ref1
ER  -