TY - JOUR
PY - 2020//
TI - Association between dopamine beta-hydroxylase polymorphism and attention function in suicide attempters with chronic schizophrenia
JO - Human psychopharmacology
A1 - Hui, Li
A1 - Hu, Wei Ming
A1 - Zhu, Zhen Hua
A1 - Gao, Song Tian
A1 - Han, Mei
A1 - Fan, Yu
A1 - Tian, Qing
A1 - Yin, Xu Yuan
A1 - Yuan, Ying
A1 - Jiang, Cai Xia
A1 - Yin, Guang Zhong
A1 - Jia, Qiu Fang
A1 - Zhang, Xiang Yang
SP - ePub
EP - ePub
VL - ePub
IS - ePub
N2 - BACKGROUND: Patients with schizophrenia are at a higher risk for suicide compared with the general population. Dopamine beta-hydroxylase (DβH) plays a key role in the conversion of dopamine to norepinephrine, which is related to suicidal behavior and cognitive regulation. OBJECTIVE: To examine whether there is the effect of DβH 5'-insertion/deletion (Ins/Del) polymorphism on cognitive performance in suicide attempters with chronic schizophrenia. METHODS: This polymorphism was detected in 114 suicide attempters and 617 non-suicide attempters with chronic schizophrenia. Cognitive performance was assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). RESULTS: The allelic and genotypic frequencies of this polymorphism between two groups did not differ after controlling for covariates (both, p >.05). There were no differences in RBANS scores between two groups after adjusting for covariates (all, p >.05). However, based on the genotype grouping in suicide attempters and non-attempters, the attention score significantly differed after adjusting for covariates (both, p <.05). Further analysis indicated that this polymorphism was associated with attention score in suicide attempters (p <.05), but not in non-suicide attempters (p >.05). CONCLUSIONS: DβH 5'-Ins/Del polymorphism was not a risk locus of suicide attempters, but it was implicated in attention regulation in suicide attempters with chronic schizophrenia. Language: en
LA - en
SN - 0885-6222
UR - http://dx.doi.org/10.1002/hup.2755
ID - ref1
ER -