TY  - JOUR
PY  - 2020//
TI  - The role of peripheral cortisol levels in suicide behavior: a systematic review and meta-analysis of 30 studies
JO  - Psychiatry research
A1  - Hernández-Díaz, Yazmín
A1  - González-Castro, Thelma Beatriz
A1  - Tovilla-Zárate, Carlos Alfonso
A1  - Juárez-Rojop, Isela Esther
A1  - López-Narváez, María Lilia
A1  - Pérez-Hernández, Nonanzit
A1  - Rodríguez-Pérez, José Manuel
A1  - Genis-Mendoza, Alma Delia
A1  - Nicolini, Humberto
SP  - e113448
EP  - e113448
VL  - 293
IS  - 
N2  - Cortisol can be considered as one biomarker for diagnosis of suicide; nevertheless, several studies have shown conflicting results. This study aimed to evaluate the levels of cortisol in individuals with suicide behavior and controls (healthy or with other psychiatric disorders). Published articles were searched on online databases (PubMed, Scopus and EBSCO). Standardized mean differences (SMD), heterogeneity, publication bias and sensitivity were assessed using the Comprehensive Meta-Analysis (CMA) statistical software. The meta-analysis comprised 30 studies that provided 1775 cases, and 2162 controls (696 healthy individuals and 1465 individuals with other psychiatric diagnoses). The pooled results revealed that cortisol levels were higher in individuals with suicide behavior (SMD = 0.92, 95%CI = 0.26; 1.57, P = 0.006; I2 = 88%, Q < 0.001) than healthy controls. However, individuals with suicide behavior showed decreased levels of cortisol in the morning. Additionally, individuals with suicide behavior showed lower levels of cortisol than psychiatric controls (SMD = -1.79, 95%CI = -3.01; -0.58, P = 0.004, I2 = 89%, Q < 0.001). Morning cortisol levels in individuals with suicide behavior were higher than morning cortisol levels in psychiatric controls. Our updated meta-analysis suggests that peripheral levels of cortisol have a role in suicide behavior.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/10.1016/j.psychres.2020.113448
ID  - ref1
ER  -