TY  - JOUR
PY  - 2020//
TI  - Weaker braking force, a new marker of worse gait stability in Alzheimer disease
JO  - Frontiers in aging neuroscience
A1  - Cheng, Qianqian
A1  - Wu, Mengxuan
A1  - Wu, Yuemin
A1  - Hu, Yaoyao
A1  - Kwapong, William Robert
A1  - Shi, Xiang
A1  - Fan, Yinying
A1  - Yu, Xin
A1  - He, Jincai
A1  - Wang, Zhen
SP  - e554168
EP  - e554168
VL  - 12
IS  - 
N2  - BACKGROUND: Braking force is a gait marker associated with gait stability. This study aimed to determine the alteration of braking force and its correlation with gait stability in Alzheimer disease (AD). <br><br>METHODS: A total of 32 AD patients and 32 healthy controls (HCs) were enrolled in this study. Gait parameters (braking force, gait variability, and fall risk) in the walking tests of Free walk, Barrier, and Count backward were measured by JiBuEn® gait analysis system. Gait variability was calculated by the coefficient of variation (COV) of stride time, stance time, and swing time. <br><br>RESULTS: The braking force of AD was significantly weaker than HCs in three walking tests (P < 0.001, P < 0.001, P = 0.007). Gait variability of AD showed significant elevation than HCs in the walking of Count backward (COVstride: P = 0.013; COVswing: P = 0.006). Fall risk of AD was significantly higher than HCs in three walking tests (P = 0.001, P = 0.001, P = 0.001). Braking force was negatively associated with fall risks in three walking tests (P < 0.001, P < 0.001, P < 0.001). There were significant negative correlations between braking force and gait variability in the walking of Free walk (COVstride: P = 0.018; COVswing: P = 0.013) and Barrier (COVstride: P = 0.002; COVswing: P = 0.001), but not Count backward (COVstride: P = 0.888; COVswing: P = 0.555). <br><br>CONCLUSION: Braking force was weaker in AD compared to HCs, reflecting the worse gait stability of AD. Our study suggests that weakening of braking force may be a new gait marker to indicate cognitive and motor impairment and predict fall risk in AD.<p />  <p>Language: en</p>
LA  - en
SN  - 1663-4365
UR  - http://dx.doi.org/10.3389/fnagi.2020.554168
ID  - ref1
ER  -