TY  - JOUR
PY  - 2020//
TI  - Vitamin D supplementation and fracture risk: evidence for a U-shaped effect
JO  - Maturitas
A1  - Anagnostis, Panagiotis
A1  - Bosdou, Julia K.
A1  - Kenanidis, Eustathios
A1  - Potoupnis, Michael
A1  - Tsiridis, Eleftherios
A1  - Goulis, Dimitrios G.
SP  - 63
EP  - 70
VL  - 141
IS  - 
N2  - During the last decade, a cascade of evidence has questioned the anti-fracture efficacy of vitamin D supplementation. In general, vitamin D status, reflected by serum 25-hydroxy-vitamin D [25(OH)D] concentrations, seems to predict fracture risk and bone mineral density (BMD). Despite the well-documented detrimental effect of vitamin D deficiency on bones, vitamin D monotherapy does not seem to reduce the risk of fractures. On the other hand, high vitamin D doses, either at monthly (60,000-100,000 IU) or daily intervals (>4000 IU), appear to be harmful with regard to falls, fracture risk and BMD, especially for people without vitamin D deficiency and at low fracture risk. Therefore, a U-shaped effect of vitamin D on the musculoskeletal system may be supported by the current evidence. Vitamin D supplementation could be of value, at daily doses of at least 800 IU, co-supplemented with calcium (1000-1200  mg/day), in elderly populations, especially those with severe vitamin D deficiency [25(OH)D <25-30  nmol/L (<10-12  ng/mL)], although its anti-fracture and anti-fall efficacy is modest. Good compliance and at least 3-5 years of therapy are required.<p />  <p>Language: en</p>
LA  - en
SN  - 0378-5122
UR  - http://dx.doi.org/10.1016/j.maturitas.2020.06.016
ID  - ref1
ER  -