TY  - JOUR
PY  - 2020//
TI  - Impact of depression on gait variability in Parkinson's disease
JO  - Clinical neurology and neurosurgery
A1  - Dragašević-Mišković, Nataša T.
A1  - Bobić, Vladislava
A1  - Kostić, Milutin
A1  - Stankovic, Iva
A1  - Radovanović, Saša
A1  - Dimitrijević, Kosta
A1  - Svetel, Marina
A1  - Petrović, Igor
A1  - Đurić-Jovičić, Milica
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVE: The goal of this study was to analyze how depression associated with Parkinson's disease (PD) affected gait variability in these patients using a dual-task paradigm. Additionally, the dependency of the executive functions and the impact of depression on gait variability were analyzed.     PATIENTS AND METHODS: Three subject groups were included: patients with PD, but no depression (PD-NonDep; 14 patients), patients with both PD and depression (PD-Dep; 16 patients) and healthy controls (HC; 15 subjects). Gait was recorded using the wireless sensors. The participants walked under four conditions: single-task, motor dual- task, cognitive dual-task, and combined dual-task. Variability of stride length, stride duration, and swing time was calculated and analyzed using the statistical methods.     RESULTS: Variability of stride duration and stride length were not significantly different between PD-Dep and PD-NonDep patients. The linear mixed model showed that swing time variability was statistically significantly higher in PD-Dep patients compared to controls (p = 0.001). Hamilton Disease Rating Scale scores were significantly correlated with the swing time variability (p = 0.01). Variability of all three parameters of gait was significantly higher while performing combined or cognitive task and this effect was more pronounced in PD-Dep group of patients.     CONCLUSIONS: Depression in PD was associated with swing time variability, and this effect was more prominent while performing a dual-task.     SIGNIFICANCE: Diagnosing and treating depression might be important for gait improvement and fall reduction in PD patients.<p />  <p>Language: en</p>
LA  - en
SN  - 0303-8467
UR  - http://dx.doi.org/10.1016/j.clineuro.2020.106324
ID  - ref1
ER  -