TY  - JOUR
PY  - 2020//
TI  - Threat-avoidance tendencies moderate the link between serotonin transporter genetic variation and reactive aggression
JO  - Frontiers in behavioral neuroscience
A1  - Peeters, Deborah G. A.
A1  - Lange, Wolf-Gero
A1  - von Borries, Anna Katinka Louise
A1  - Franke, Barbara
A1  - Volman, Inge
A1  - Homberg, Judith R.
A1  - Verkes, Robbert-Jan
A1  - Roelofs, Karin
SP  - e562098
EP  - e562098
VL  - 14
IS  - 
N2  - The short (S) allele of the serotonin transporter-linked promoter region (5-HTTLPR) polymorphism has been linked to reactive aggression in men, but this association is less consistent in females. Reactive aggression has been particularly described as a result of fear-driven defense to threat, but how this interaction between defensive behavior and aggression is expressed in S-allele carriers remains unknown. In order to explore this interplay between 5-HTTLPR genotype, defensive behavior and reactive aggression, we combined genotyping with objective measures of action tendencies toward angry faces in an approach-avoidance task (AAT) and reactive aggression in the Taylor aggression paradigm (TAP) in healthy females, N = 95. This study shows that female S-allele carriers in general display increased implicit reactive aggression (administering aversive white noise) toward opponents. Furthermore, we found that threat-avoidance tendencies moderate the association between 5-HTTLPR genotype and aggression displayed on the TAP. Together, these findings indicate a positive correlation between avoidance of angry faces in the AAT and reactive aggression in the TAP exclusively present in S-allele carriers.<p />  <p>Language: en</p>
LA  - en
SN  - 1662-5153
UR  - http://dx.doi.org/10.3389/fnbeh.2020.562098
ID  - ref1
ER  -