TY  - JOUR
PY  - 2020//
TI  - Spatial patterns of amyloid deposition in patients with chronic focal or diffuse traumatic brain injury using 18F-FPYBF-2 PET
JO  - Neuropsychiatric disease and treatment
A1  - Ubukata, Shiho
A1  - Oishi, Naoya
A1  - Higashi, Tatsuya
A1  - Kagawa, Shinya
A1  - Yamauchi, Hiroshi
A1  - Okuyama, Chio
A1  - Watanabe, Hiroyuki
A1  - Ono, Masahiro
A1  - Saji, Hideo
A1  - Aso, Toshihiko
A1  - Murai, Toshiya
A1  - Ueda, Keita
SP  - 2719
EP  - 2732
VL  - 16
IS  - 
N2  - AIM: Amyloid-β (Aβ) accumulation, accelerated by traumatic brain injury (TBI), may play a crucial role in neurodegeneration in chronic-stage TBI. The injury type could influence Aβ dynamics because of TBI's complex, heterogeneous nature. We, therefore, investigated spatial patterns of amyloid deposition according to injury type after TBI using 5-(5-(2-(2-(2-[F]-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylpyridin-2-amine (18F-FPYBF-2) positron emission tomography (PET).     Methods: Altogether, 20 patients with chronic TBI [12 with focal injury, 8 with diffuse axonal injury (DAI)] underwent 18F-FPYBF-2 PET, structural magnetic resonance imaging (MRI), and neuropsychological examination. Additionally, 50 healthy controls underwent either 18F-FPYBF-2 PET (n=30) or structural MRI (n=20).     Results: Standardized uptake value ratio (SUVR) on PET images and regional brain volumes were measured in four cortical (frontal, parietal, occipital, temporal) and subcortical (combined caudate, putamen, pallidum, thalamus) regions. Patients with DAI showed significantly increased (compared with controls) SUVR in occipital and temporal cortices and decreased brain volume in occipital cortex (corrected p < 0.05). Although patients with focal injury showed decreased SUVR in all regions except occipital cortex, there were no significant differences (compared with controls) in the SUVR in any regions. There were no significant correlations between increased SUVR and neuropsychological impairments in patients with DAI.     Conclusion: Varying spatial patterns of amyloid deposition suggest amyloid pathology diversity depending on the injury type in chronic-TBI patients.<p />  <p>Language: en</p>
LA  - en
SN  - 1176-6328
UR  - http://dx.doi.org/10.2147/NDT.S268504
ID  - ref1
ER  -