TY  - JOUR
PY  - 2020//
TI  - Increased nocturnal arterial pulsation frequencies of obstructive sleep apnoea  patients is associated with an increased number of lapses in a psychomotor vigilance  task
JO  - ERJ open research
A1  - Kainulainen, Samu
A1  - Duce, Brett
A1  - Korkalainen, Henri
A1  - Leino, Akseli
A1  - Huttunen, Riku
A1  - Kalevo, Laura
A1  - Arnardottir, Erna S.
A1  - Kulkas, Antti
A1  - Myllymaa, Sami
A1  - Töyräs, Juha
A1  - Leppänen, Timo
SP  - e277
EP  - e277
VL  - 6
IS  - 4
N2  - OBJECTIVES: Besides hypoxaemia severity, heart rate variability has been linked to  cognitive decline in obstructive sleep apnoea (OSA) patients. Thus, our aim was to  examine whether the frequency domain features of a nocturnal photoplethysmogram  (PPG) can be linked to poor performance in the psychomotor vigilance task (PVT). <br><br>METHODS: PPG signals from 567 suspected OSA patients, extracted from Type 1  diagnostic polysomnography, and corresponding results of PVT were retrospectively  examined. The frequency content of complete PPGs was determined, and analyses were  conducted separately for men (n=327) and women (n=240). Patients were grouped into  PVT performance quartiles based on the number of lapses (reaction times ≥500 ms) and  within-test variation in reaction times. The best-performing (Q1) and  worst-performing (Q4) quartiles were compared due the lack of clinical thresholds in  PVT. <br><br>RESULTS: We found that the increase in arterial pulsation frequency (APF) in  both men and women was associated with a higher number of lapses. Higher APF was  also associated with higher within-test variation in men, but not in women. Median  APF (β=0.27, p=0.01), time spent under 90% saturation (β=0.05, p<0.01), female sex  (β=1.29, p<0.01), older age (β=0.03, p<0.01) and subjective sleepiness (β=0.07,  p<0.01) were significant predictors of belonging to Q4 based on lapses. Only female  sex (β=0.75, p<0.01) and depression (β=0.91, p<0.02) were significant predictors of  belonging to Q4 based on the within-test variation. <br><br>CONCLUSIONS: In conclusion,  increased APF in PPG provides a possible polysomnography indicator for deteriorated  vigilance especially in male OSA patients. This finding highlights the connection  between cardiorespiratory regulation, vigilance and OSA. However, our results  indicate substantial sex-dependent differences that warrant further prospective  studies.<p />  <p>Language: en</p>
LA  - en
SN  - 2312-0541
UR  - http://dx.doi.org/10.1183/23120541.00277-2020
ID  - ref1
ER  -