TY  - JOUR
PY  - 2020//
TI  - Comprehensive database and individual patient data meta-analysis of randomised controlled trials on psychotherapies reducing suicidal thoughts and behaviour: study protocol
JO  - BMJ open
A1  - Hu, Mandy Xian
A1  - Palantza, Christina
A1  - Setkowski, Kim
A1  - Gilissen, Renske
A1  - Karyotaki, Eirini
A1  - Cuijpers, Pim
A1  - Riper, Heleen
A1  - De Beurs, Derek
A1  - Nuij, Chani
A1  - Christensen, Helen
A1  - Calear, Alison
A1  - Werner-Seidler, Aliza
A1  - Hoogendoorn, Adriaan
A1  - van Balkom, Anton
A1  - Eikelenboom, Merijn
A1  - Smit, Jan
A1  - van Ballegooijen, Wouter
SP  - e037566
EP  - e037566
VL  - 10
IS  - 12
N2  - INTRODUCTION: Psychotherapy may reduce suicidal thoughts and behaviour, but its effectiveness is not well examined. Furthermore, conventional meta-analyses are unable to test possible effects of moderators affecting this relationship. This protocol outlines the building of a comprehensive database of the literature in this research field. In addition, we will conduct an individual patient data meta-analysis (IPD-MA) to establish the effectiveness of psychotherapy in reducing suicidality, and to examine which factors moderate the efficacy of these interventions.     METHODS AND ANALYSIS: To build a comprehensive database, randomised controlled trials examining the effect of any psychotherapy targeting any psychiatric disorder on suicidal thoughts or behaviour will be identified by running a systematic search in PubMed, Embase, PsycINFO, Web of Science, Scopus and The Cochrane Central Register of Controlled Trials from data inception to 12 August 2019. For the IPD-MA, we will focus on adult outpatients with suicidal ideation or behaviour. In addition, as a comparison group we will focus on a control group (waiting-list, care as usual or placebo). A 1-stage IPD-MA will be used to determine the effectiveness of psychotherapy on suicidal ideation, suicide attempts and/or suicide deaths, and to investigate potential patient-related and intervention-related moderators. Subgroup and sensitivity analyses will be conducted to test the robustness of the findings. Additionally, a conventional MA will be conducted to determine the differences between studies that provided IPD and those that did not. IPD-MA may determine the effectiveness of psychotherapy in reducing suicidality and provide insights into the moderating factors influencing the efficacy of psychotherapy. Answering these questions will inform mental healthcare practitioners about optimal treatments for different groups of individuals with suicidal ideation and/or behaviour and consequently help to reduce suicide risk.     ETHICS AND DISSEMINATION: An ethical approval is not required for this study. The results will be published in a peer-review journal.     PROSPERO REGISTRATION NUMBER: CRD42020140573.<p />  <p>Language: en</p>
LA  - en
SN  - 2044-6055
UR  - http://dx.doi.org/10.1136/bmjopen-2020-037566
ID  - ref1
ER  -