TY  - JOUR
PY  - 2020//
TI  - Altered functional connectivity differences in salience network as a neuromarker of suicide risk in euthymic bipolar disorder patients
JO  - Frontiers in human neuroscience
A1  - Sobczak, Anna Maria
A1  - Bohaterewicz, Bartosz
A1  - Marek, Tadeusz
A1  - Fafrowicz, Magdalena
A1  - Dudek, Dominika
A1  - Siwek, Marcin
A1  - Tereszko, Anna
A1  - Krupa, Anna
A1  - Bryll, Amira
A1  - Chrobak, Adrian Andrzej
SP  - e585766
EP  - e585766
VL  - 14
IS  - 
N2  - OBJECTIVE: The occurrence of death by suicide in patients diagnosed with bipolar disorder is as much as 60 times greater than in the general population. Even during the state of euthymia patients are characterized by suicide risk. The aim of the study is to investigate the baseline brain activity in euthymic bipolar disorder patients in regard to suicide risk. We hypothesized that patients compared to healthy control group will demonstrate altered functional connectivity among resting state networks which will be directly related to current suicide risk.     Method: 41 subjects were enrolled in the study consisting control group (n = 21) and euthymic bipolar disorder patients group (n = 20). Functional magnetic resonance imaging was used to evaluate resting state brain activity and ROI-ROI functional connectivity analysis was performed. Suicidal risk was estimated using The Suicide Behaviors Questionnaire-Revised.     Results: A two sample t-test revealed decreased functional connectivity between regions involved in the salience network in patients compared to the control group. This decrease was negatively correlated with current suicide risk.     Conclusion: Obtained results suggest the association between risk of suicide and activity of regions responsible for functions such as learning from mistakes, prospective thinking, and sensory integration.<p />  <p>Language: en</p>
LA  - en
SN  - 1662-5161
UR  - http://dx.doi.org/10.3389/fnhum.2020.585766
ID  - ref1
ER  -