TY  - JOUR
PY  - 2020//
TI  - Acute phenobarbital poisoning for the management of seizures in new-borns and children; a systematic literature review
JO  - CNS and neurological disorders drug targets
A1  - Ghorani-Azam, Adel
A1  - Balali-Mood, Mahdi
A1  - Riahi-Zanjani, Bamdad
A1  - Darchini-Maragheh, Emadodin
A1  - Sadegh, Mahmood
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVES: While phenobarbital (PB) is commonly used for the management of seizures in newborns and pediat-rics, its administration may accompany with acute poisoning. We aimed to review the literature to find out the frequency of PB poisonings in newborns and children with seizures.     METHOD: Literature search was performed by two independent reviewers to find relevant articles about PB toxicity in neo-nates and pediatrics that were treated for seizure.     RESULTS: 18 articles met the inclusion criteria and were included to this systematic review. The main reasons of PB poison-ing in studied patients were therapeutic intoxication. Reported signs of PB poisoning were lethargy, sedation, lack of suck-ing, fever, skin rash, hepatic inflammation and alopecia. Moreover, respiratory depression, encephalopathy, myocardial fail-ure, syndrome of inappropriate antidiuretic hormone, and coma were among the complications of acute PB toxicity in chil-dren and infants.     CONCLUSION: PB therapy for the management of seizures in newborns and children might be associated with poisoning. Alt-hough supportive and symptomatic treatments are available for PB overdose, it should be administered with caution, using drug monitoring to avoid toxicity.<p />  <p>Language: en</p>
LA  - en
SN  - 1871-5273
UR  - http://dx.doi.org/10.2174/1871527319666201207205916
ID  - ref1
ER  -