TY  - JOUR
PY  - 2020//
TI  - Is short-term antidepressant treatment effective and safe in bipolar depression? Results from an observational multicenter study
JO  - Human psychopharmacology
A1  - Tundo, Antonio
A1  - Musetti, Laura
A1  - Del Grande, Claudia
A1  - de Filippis, Rocco
A1  - Proietti, Luca
A1  - Cambiali, Erika
A1  - Franceschini, Caterina
A1  - Dell'osso, Liliana
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVES: To investigate the short-term effectiveness and the short-term and long-term safety of acute antidepressant (AD) treatment of bipolar depression in a naturalistic setting.     METHODS: Patients with bipolar (n = 86) or unipolar (n = 111) depression were consecutively recruited and treated with AD (combined with mood stabilizer [MS] and/or second-generation antipsychotics in bipolar depression). Exclusion criteria were mixed depression, high mood instability, previous predominantly mixed depression (both bipolar and unipolar depression), rapid cycling course and previous switch AD-emerging (bipolar depression).     RESULTS: After 12 weeks of treatment, no difference was found in remission, response and improvement rates between bipolar and unipolar depression. Concerning short-term safety, switching and suicidality did not differ significantly between the two groups, and no suicide attempt was observed. Concerning long-term safety, patients with bipolar depression had a significant reduction of depressive and total recurrences during the year of follow-up, compared to the year before entering the study, without significant changes in (hypo)mania and mixed depression recurrences, and suicide rates.     CONCLUSIONS: Acute AD treatment of bipolar depression is effective in the short-term and safe in the short- and long-term, when administered in combination with MSs and/or second-generation antipsychotics, with a low risk of switch, mixed depression and cycle acceleration.<p />  <p>Language: en</p>
LA  - en
SN  - 0885-6222
UR  - http://dx.doi.org/10.1002/hup.2773
ID  - ref1
ER  -