TY  - JOUR
PY  - 2020//
TI  - Cardiovascular autonomic dysfunction and falls in people with multiple sclerosis: is  there a link? An opinion article
JO  - Frontiers in neuroscience
A1  - Zanotto, Tobia
A1  - Hernandez, Manuel E.
A1  - Medrano, Cristina N.
A1  - Wilund, Kenneth R.
A1  - Sosnoff, Jacob J.
SP  - e610917
EP  - e610917
VL  - 14
IS  - 
N2  - Falls and fall-related injuries are highly prevalent in people living with multiple sclerosis (MS). A multinational meta-analysis revealed that 56% of people with MS (pwMS) fall at least once in any 3-month period (Nilsagård et al., 2015) and 11-42% of falls are injurious (Gunn et al., 2014; Mazumder et al., 2014). Falls are of clinical concern as they increase the burden of morbidity and mortality (Grossman et al., 2018). Mobility impairments, progressive MS, and cognitive impairment are the most commonly reported risk factors for falls in this clinical population (Gunn et al., 2013; Giannı̀ et al., 2014; Sosnoff and Sung, 2015).     Despite the recent progress in disease-modifying medical treatments, as well as the numerous randomized controlled trials aiming to reduce falls, the evidence regarding effectiveness of interventions for fall-prevention in MS remains inconclusive (Hayes et al., 2019). Although such inconclusiveness is potentially related to the lack of methodological quality of intervention studies, it also highlights the need for accurate characterization of fall-etiology in this patient population. The success of fall-prevention programs is often based on their ability to effectively target underlying physiologic conditions. Therefore, in order to correctly prioritize rehabilitation strategies in MS, it is essential to identify all modifiable or partially-modifiable risk factors for falls.     Multiple sclerosis (MS) is characterized by damage to the central nervous system (CNS) as a result of inflammatory demyelination and neurodegeneration (Ghasemi et al., 2017). While such damage often translates into impairments of cognition and motor function, which are reasonably recognized as the main determinants of falls (Gunn et al., 2013), a growing body of research has explored the relationship between MS-related CNS damage and autonomic dysfunction (Racosta et al., 2015; Findling et al., 2020). Autonomic dysfunction can severely impact the quality of life in pwMS and often affects multiple organs and systems including the bladder, bowels, heart, as well as sexual and sudomotor functions (McDougall and McLeod, 2003; Lensch and Jost, 2011). A meta-analysis has concluded that cardiovascular autonomic dysfunction (CAD) is highly prevalent, with 19-42% of pwMS affected by this condition (Racosta et al., 2015). Importantly, CAD is one of the main drivers of orthostatic hypotension (OH) and contributes to symptoms of orthostatic intolerance, such as dizziness, which can directly or indirectly increase the risk of falling (Magkas et al., 2019). In this article, we aimed to outline the potential relationship between CAD and falls in pwMS...<p />  <p>Language: en</p>
LA  - en
SN  - 1662-4548
UR  - http://dx.doi.org/10.3389/fnins.2020.610917
ID  - ref1
ER  -