TY  - JOUR
PY  - 2021//
TI  - The effect of activated charcoal on drug exposure following intravenous administration: a meta-analysis
JO  - Basic and Clinical Pharmacology and Toxicology
A1  - Skov, Kenneth
A1  - Graudal, Niels A.
A1  - Jürgens, Gesche
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Activated charcoal (AC) is a cheap, safe and readily available treatment that has been used for treatment of drug poisonings for decades (1). It is well documented  that AC reduces systemic drug exposure(2). However, AC has not been consistently  shown to affect clinical endpoints like mortality and morbidity. Thus, AC treatment  is based on the theoretical assumption that reduced drug exposure translates into  improved clinical outcome. Accordingly, current international guidelines from  AACT/EAPCCT (American Academy of Clinical Toxicology and European Association of  Poisons Centres and Clinical Toxicologists) are based primarily on studies of  reduced drug exposure in healthy volunteers and expert consensus (3,4).<p />  <p>Language: en</p>
LA  - en
SN  - 1742-7835
UR  - http://dx.doi.org/10.1111/bcpt.13553
ID  - ref1
ER  -