TY  - JOUR
PY  - 2021//
TI  - Tractography-pathology correlations in traumatic brain injury: a TRACK-TBI Study
JO  - Journal of neurotrauma
A1  - Nolan, Amber L.
A1  - Iacono, Diego
A1  - Petersen, Cathrine
A1  - Stevens, Allison
A1  - Jain, Sonia
A1  - van der Kouwe, Andre
A1  - Edlow, Brian L.
A1  - Wang, Ruopeng
A1  - Diamond, Bram
A1  - Diaz-Arrastia, Ramon
A1  - Keene, C. Dirk
A1  - Manley, Geoffrey T.
A1  - Perl, Daniel
A1  - Fischl, Bruce
A1  - Mukherjee, Pratik
A1  - Mac Donald, Christine L.
A1  - Markowitz, Amy J.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Diffusion tractography MRI can infer changes in network connectivity in patients with traumatic brain injury (TBI), but the pathological substrates of disconnected  tracts have not been well-defined due to a lack of high-resolution imaging with  histopathological validation. We developed an ex vivo MRI protocol to analyze tract  terminations at 750 μm isotropic resolution, followed by histopathologic evaluation  of white matter pathology, and applied these methods to a 60-year-old man who died  26 days after TBI. Analysis of 74 cerebral hemispheric white matter regions revealed  a heterogeneous distribution of tract disruptions. Associated histopathology  identified variable white matter injury with patchy deposition of amyloid precursor  protein and loss of neurofilament-positive axonal processes, myelin dissolution,  astrogliosis, microgliosis, and perivascular hemosiderin-laden macrophages. Multiple  linear regression revealed that tract disruption strongly correlated with the  density of amyloid precursor protein (APP)-positive axonal swellings and  neurofilament loss. Ex vivo diffusion MRI can detect tract disruptions in the human  brain that reflect axonal injury.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2020.7373
ID  - ref1
ER  -