TY  - JOUR
PY  - 2021//
TI  - Reported maternal childhood maltreatment experiences, amygdala activation and functional connectivity to infant cry
JO  - Social cognitive and affective neuroscience
A1  - Tribble, Rebekah
A1  - Kim, Pilyoung
A1  - Erhart, Andrew
A1  - Stoddard, Joel
A1  - Olsavsky, Aviva K.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Maternal childhood maltreatment experiences (CME) may influence responses to infants and affect child outcomes. We examined associations between CME and mothers' neural  responses and functional connectivity to infant distress. We hypothesized that  mothers with greater CME would exhibit higher amygdala reactivity and  amygdala-supplementary motor area (SMA) functional connectivity to own infant's  cries. Postpartum mothers (N=57) assessed for CME completed an fMRI task with cry  and white-noise stimuli. Amygdala region-of-interest and psychophysiological  interaction analyses were performed. Our models tested associations of CME with  activation and connectivity during task-conditions (own/other; cry/noise). Exploratory analyses with parenting behaviors were performed. Mothers with higher  CME exhibited higher amygdala activation to own baby's cries vs. other stimuli  (F1,392=6.9, p<0.01, N=57) and higher differential connectivity to cry vs. noise  between amygdala and SMA (F1,165 = 22.3, p<0.001). Exploratory analyses revealed  positive associations between both amygdala activation and connectivity and maternal  non-intrusiveness (ps<0.05). Increased amygdala activation to own infant's cry and  higher amygdala-SMA functional connectivity suggest motor responses to baby's  distress. These findings were associated with less intrusive maternal behaviors. Follow up studies might replicate these findings, add more granular parenting  assessments, and explore how cue processing leads to motivated maternal approach in  clinical populations.<p />  <p>Language: en</p>
LA  - en
SN  - 1749-5016
UR  - http://dx.doi.org/10.1093/scan/nsab005
ID  - ref1
ER  -