TY  - JOUR
PY  - 2021//
TI  - Genetic variation in neuropeptide Y interacts with childhood trauma to influence anxiety sensitivity
JO  - Anxiety, stress, and coping
A1  - Womersley, Jacqueline Samantha
A1  - Martin, Lindi
A1  - van der Merwe, Lize
A1  - Seedat, Soraya
A1  - Hemmings, Sian Megan Joanna
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND AND OBJECTIVES: Anxiety sensitivity (AS) refers to a fear of the negative implications of anxiety, and arises due to gene-environment interactions. We investigated whether genetic variation in two neuropeptides implicated in the stress response, neuropeptide Y (NPY) and pituitary adenylate cyclase-activating polypeptide receptor 1, interacted with childhood trauma (CT) to influence AS. DESIGN AND METHODS: This cross-sectional study examined the CT x genetic variant effects on AS in 951 adolescents who self-identified as Xhosa or South African Colored (SAC) ethnicity. <br><br>RESULTS: In Xhosa females, the NPY rs5573 A allele and rs3037354 deletion variant were associated with increased (p = 0.035) and decreased (p = 0.034) AS, respectively. The interaction of CT and the NPY rs5574 A allele increased AS in SAC female participants (p = 0.043). The rs3037354 deletion variant protected against AS with increased CT in SAC male participants (p = 0.011). <br><br>CONCLUSIONS: The NPY rs5574 A allele and rs3037354 deletion variant interact with CT to act as risk and protective factors, respectively, for AS in an ethnicity- and sex- differentiated manner. Our results reaffirm the role of NPY and gene-environment interactions in anxiety-related behaviors and reinforce the need for psychiatric genetics studies in diverse populations.<p />  <p>Language: en</p>
LA  - en
SN  - 1061-5806
UR  - http://dx.doi.org/10.1080/10615806.2021.1876225
ID  - ref1
ER  -