TY  - JOUR
PY  - 2000//
TI  - Blood propofol concentration and psychomotor effects on driving skills
JO  - British journal of anaesthesia
A1  - Grant, S. A.
A1  - Murdoch, James
A1  - Millar, K.
A1  - Kenny, G. N.
SP  - 396
EP  - 400
VL  - 85
IS  - 3
N2  - We studied psychomotor performance in 10 healthy volunteers during recovery after a target-controlled infusion of propofol. Choice reaction time, dual task tracking with secondary reaction time and a within-list recognition task were assessed at target blood propofol concentrations of 0.8, 0.4 and 0.2 microgram ml-1. Performance was impaired most at the highest blood propofol concentration (choice reaction time increased by a mean of 247 ms and secondary reaction time by a mean of 178 ms). Choice reaction time and dual task tracking with secondary reaction time were the most sensitive and reliable methods of assessment (significant difference from baseline (P < 0.05) at a propofol concentration of 0.2 microgram ml-1 with choice and secondary reaction time testing). Within-list recognition assessment of memory was not sufficiently sensitive at very low propofol concentrations. The impairment in choice and secondary reaction time with a blood propofol concentration of 0.2 microgram ml-1 was less than that observed with a blood alcohol concentration of 50 mg 100 ml-1 and no greater than that observed with a blood alcohol concentration of 20 mg 100 ml-1 in a previous study involving healthy volunteers.<p />  <p>Language: en</p>
LA  - en
SN  - 0007-0912
UR  - http://dx.doi.org/
ID  - ref1
ER  -