TY  - JOUR
PY  - 2021//
TI  - Evaluation of allergic reactions following intravenous infusion of polyvalent antivenom in snakebite patients
JO  - Anti-inflammatory and anti-allergy agents in medicinal chemistry
A1  - Mahmoudi, Ghafar-Ali
A1  - Ahadi, Maryam
A1  - Fouladvand, Ali
A1  - Rezaei, Bareza
A1  - Bodagh, Zahra
A1  - Astaraki, Peyman
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Antivenom is a gold-standard treatment for snakebite envenoming. However, adverse reactions to snake antivenom are common in many parts. <br><br>OBJECTIVE: The aim of this study was to evaluate the allergic reactions following intravenous administration of antivenom sera. <br><br>METHODS: This was retrospective study, conducted snakebites patients referred to the Rahimi Hospital in Khorramabad. The files of these patients were accessed for demographic data, snakebite-related data, treatment provided, clinical presentation and allergic reaction status as a result of antivenom treatment. <br><br>RESULTS: 141 cases were investigated including 73.8% male and 26.2% female patients. The mean age of the patients was 38.1±17.1years. Age group 30-39 years accounted for highest number of snakebite cases (24.1%). A majority of victims (89.4%) were from the rural areas. Most of the patients (51.8%) were bitten in the spring and highest number of snakebite were reported in May (39.1%). The most common site of snakebite was lower extremities (50.4%) and upper extremities (44.7%). Among clinical feature of snakebite, pain was the most prevalent in 135 cases (95.7%) followed by swelling (83.7%). The mean antivenom vials used were 6.5±3.7 vials. Allergic reactions occurred in 6 patients (4.26%); reactions were mild in 5 patients and sever in 1patient. The commonest presentation was maculopapular rash (1.4%) and the least common were headache (0.71%), nausea (0.71%), fever (0.71) and hypotension (0.71%). <br><br>CONCLUSION: Snakebite is one of the significantlife-threatening environmental events.Immediate antivenom treatment can reduce mortality however, patients should be carefully monitored for adverse allergic reactions.<p />  <p>Language: en</p>
LA  - en
SN  - 1871-5230
UR  - http://dx.doi.org/10.2174/1871523020666210204143756
ID  - ref1
ER  -