TY  - JOUR
PY  - 2021//
TI  - Ability of S100B to predict post-concussion syndrome in paediatric patients who present to the emergency department with mild traumatic brain injury
JO  - British journal of neurosurgery
A1  - Kelmendi, Fatos M.
A1  - Morina, Arsim A.
A1  - Mekaj, Agon Y.
A1  - Dragusha, Shefki
A1  - Ahmeti, Feti
A1  - Alimehmeti, Ridvan
A1  - Morina, Qamile
A1  - Berisha, Murat
A1  - Krasniqi, Blerim
A1  - Kerolli, Berat
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - INTRODUCTION: Among children who sustain mild traumatic brain injury (mTBI), 10-30% develop a cluster of cognitive, physical, and emotional symptoms commonly referred to as post-concussion syndrome (PCS). Symptoms typically resolve within 7-10 days, but a minority of patients report symptoms that persist for months or even years. The aim of our study was to identify a neurobiochemical marker after mTBI that can predict the presence of post-concussion syndrome three months after head injury in paediatric patients. <br><br>MATERIALS AND METHODS: Children between 7 and 16 years of age who had head trauma and no other complaints were included. Three months after the initial visit, participants or parents/guardians were interviewed in person about the children's PCS symptoms using the Rivermead Post-Concussion Symptoms Questionnaire (RPQ). <br><br>RESULTS: The mean value of S100B protein in serum in 38 patients without signs of PCS was 0.266 μg L(-1), with a 95% confidence interval (CI) of 0.221 - 0.310 μg L(-1). Among the 22 patients with signs of PCS, the mean value of S100B protein in serum was 0.845 μg L(-1), with a 95% CI of 0.745-0.945 μg L(-1). Patients with signs of PCS had higher S100B protein levels than those without signs of PCS (p < 0.0001). <br><br>CONCLUSIONS: Our prospective study showed that S100B protein is a useful neurobiomarker for detecting paediatric patients at risk for post-concussion syndrome. We found that the biomarker S100B correlated with the severity of traumatic brain injury (number of lesions on CT) and the presence of post-concussion syndrome.<p />  <p>Language: en</p>
LA  - en
SN  - 0268-8697
UR  - http://dx.doi.org/10.1080/02688697.2021.1878487
ID  - ref1
ER  -