TY  - JOUR
PY  - 2021//
TI  - Behavioral and myelin-related abnormalities following blast-induced mild traumatic brain injury in mice
JO  - Journal of neurotrauma
A1  - Nonaka, Mio
A1  - Taylor, William W.
A1  - Bukalo, Olena
A1  - Tucker, Laura T.
A1  - Fu, Amanda H.
A1  - Kim, Yeonho
A1  - McCabe, Joseph T.
A1  - Holmes, Andrew
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - In civilian and military settings, mild traumatic brain injury (mTBI) is a common consequence of impacts to the head, sudden blows to the body, and exposure to high-energy atmospheric shockwaves from the blast. In some cases, mTBI from blast exposure results in long-term emotional and cognitive deficits and an elevated risk for certain neuropsychiatric diseases. Here, we tested the effects of mTBI on various forms of auditory-cued fear learning and other measures of cognition in male C57BL/6J mice following single or repeated blast exposure (bTBI). bTBI produced an abnormality in the temporal organization of cue-induced freezing behavior in a conditioned trace fear test. Spatial working memory, evaluated by the Y-maze task performance, was also deleteriously affected by bTBI. RT-qPCR analysis for glial markers indicated an alteration in the expression of myelin-related genes in the hippocampus and corpus callosum one to eight weeks after bTBI. Immunohistochemical and ultrastructural analyses detected bTBI-related myelin and axonal damage in the hippocampus and corpus callosum. Together these data suggest a possible link between blast-induced mTBI, myelin/axonal injury, and cognitive dysfunction.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2020.7254
ID  - ref1
ER  -