TY  - JOUR
PY  - 2021//
TI  - A rare case of Holmes tremor in a worker with occupational carbon monoxide poisoning
JO  - American journal of industrial medicine
A1  - Rutchik, Jonathan
A1  - Bowler, Rosemarie M.
A1  - Ratner, Marcia H.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Parkinsonism and encephalopathy are frequently seen in patients who survive carbon monoxide (CO) poisoning. Neurological findings associated with CO poisoning can emerge immediately after cessation of exposure or following a brief period of pseudo-recovery. When present, the tremor associated with CO poisoning is typical of the postural/intention type. Here, we report on a rare case of toxic encephalopathy with a dominant-hand Holmes-type tremor, characterized by resting, as well as postural and kinetic/intentional components, in a previously healthy 53-year-old man exposed to CO while actively engaged in the process of performing a physically demanding skilled labor task. The unique neuropathological and functional changes that give rise to Holmes-type tremor and how this relates to the selective vulnerability of the inhibitory indirect pathway of the basal ganglia to glutamatergic excitotoxicity mediated by tissue hypoxia are discussed.<p />  <p>Language: en</p>
LA  - en
SN  - 0271-3586
UR  - http://dx.doi.org/10.1002/ajim.23235
ID  - ref1
ER  -