TY  - JOUR
PY  - 2021//
TI  - Associations of sleep phenotypes with severe intentional self-harm: a prospective analysis of the UK Biobank cohort
JO  - Sleep
A1  - Lei, Binbin
A1  - Zhang, Jihui
A1  - Chen, Sijing
A1  - Chen, Jie
A1  - Yang, Lulu
A1  - Ai, Sizhi
A1  - Chan, Ngan Yin
A1  - Wang, Jing
A1  - Dai, Xi-Jian
A1  - Feng, Hongliang
A1  - Liu, Yaping
A1  - Li, Shirley Xin
A1  - Jia, Fujun
A1  - Wing, Yun-Kwok
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - STUDY OBJECTIVES: We aimed to investigate the prospective associations of sleep phenotypes with severe intentional self-harm (ISH) in middle-aged and older adults. <br><br>METHODS: A total of 499,159 participants (mean age: 56.55 ± 8.09 years; female: 54.4%) were recruited from the UK Biobank between 2006 and 2010 with follow-up until February 2016 in this population-based prospective study. Severe ISH was based on hospital inpatient records or a death cause of ICD-10 codes X60-X84. Patients with hospitalized diagnosis of severe ISH before the initial assessment were excluded. Sleep phenotypes, including sleep duration, chronotype, insomnia, sleepiness, and napping, were assessed at the initial assessments. Cox regression analysis was used to estimate temporal associations between sleep phenotypes and future risk of severe ISH. <br><br>RESULTS: During a follow-up period of 7.04 years (SD: 0.88), 1,219 participants experienced the first hospitalization or death related to severe ISH. After adjusting for demographics, substance use, medical diseases, mental disorders, and other sleep phenotypes, short sleep duration (HR: 1.50, 95% CI: 1.23-1.83, P <.001), long sleep duration (HR: 1.56, 95% CI: 1.15-2.12, P =.004), and insomnia (usually: HR: 1.57, 95% CI: 1.31-1.89, P <.001) were significantly associated with severe ISH. Sensitivity analyses excluding participants with mental disorders preceding severe ISH yielded similar results. <br><br>CONCLUSION: The current study provides the empirical evidence of the independent prediction of sleep phenotypes, mainly insomnia, short and long sleep duration, for the future risk of severe ISH among middle-aged and older adults.<p />  <p>Language: en</p>
LA  - en
SN  - 0161-8105
UR  - http://dx.doi.org/10.1093/sleep/zsab053
ID  - ref1
ER  -