TY  - JOUR
PY  - 2020//
TI  - Depression following traumatic brain injury: a comprehensive overview
JO  - Reviews in the neurosciences
A1  - Fakhoury, Marc
A1  - Shakkour, Zaynab
A1  - Kobeissy, Firas
A1  - Lawand, Nada
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Traumatic brain injury (TBI) represents a major health concern affecting the neuropsychological health; TBI is accompanied by drastic long-term adverse complications that can influence many aspects of the life of affected individuals. A substantial number of studies have shown that mood disorders, particularly depression, are the most frequent complications encountered in individuals with TBI. Post-traumatic depression (P-TD) is present in approximately 30% of individuals with TBI, with the majority of individuals experiencing symptoms of depression during the first year following head injury. To date, the mechanisms of P-TD are far from being fully understood, and effective treatments that completely halt this condition are still lacking. The aim of this review is to outline the current state of knowledge on the prevalence and risk factors of P-TD, to discuss the accompanying brain changes at the anatomical, molecular and functional levels, and to discuss current approaches used for the treatment of P-TD.<p />  <p>Language: en</p>
LA  - en
SN  - 0334-1763
UR  - http://dx.doi.org/10.1515/revneuro-2020-0037
ID  - ref1
ER  -