TY  - JOUR
PY  - 2021//
TI  - Antihistamine-related deaths in England: are the high safety profiles of antihistamines leading to their unsafe use?
JO  - British journal of clinical pharmacology
A1  - Oyekan, Princess J.
A1  - Gorton, Hayley C.
A1  - Copeland, Caroline S.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - AIM: Antihistamines are routinely taken to control allergic reactions or sedation to induce sleep. There are, however, growing concerns regarding sedating antihistamine misuse. This research aims to evaluate deaths related to antihistamines in England occurring during 2000-2019. <br><br>METHOD: Cases reported to the National Programme on Substance Abuse Deaths from England occurring in 2000-2019 with antihistamine detections at post-mortem were extracted for analysis. <br><br>RESULTS: 1666 antihistamine post-mortem detections were identified from 1537 cases. Sedating antihistamines available for purchase under pharmacist supervision but without need for a prescription (pharmacy-only [P] medications) were present in a significant majority of cases (85.2%, p<0.01). Despite an increasing trend for antihistamine-related deaths over time, the proportion of deaths where an antihistamine was implicated declined over the same period. Specific concerns with regards to the misuse of these pharmacy-only sedating antihistamines are raised with regards to the significant proportion of cases which were concluded as suicide (20.9%, p<0.01), and the high prevalence of their use in combination with other CNS depressants (94.8% of cases). <br><br>CONCLUSION: This is the first report in over 40 years regarding antihistamine-related mortality from England. The rising trend in sedating antihistamine-related deaths may be contributed to by their increasing availability and the perceived negligible dangers associated with antihistamines, both from the general public and learned professionals. Awareness of the dangerous sedative properties that some antihistamines possess is, however, heightened in individuals deliberately seeking these effects. Urgent review of sedating antihistamines currently assigned under the pharmacy-only classification is needed to achieve antihistamine harm reduction.<p />  <p>Language: en</p>
LA  - en
SN  - 0306-5251
UR  - http://dx.doi.org/10.1111/bcp.14819
ID  - ref1
ER  -