TY - JOUR PY - 2007// TI - Violent persons with schizophrenia and comorbid disorders: a functional magnetic resonance imaging study JO - Schizophrenia Research A1 - Joyal, Christian C. A1 - Putkonen, A. A1 - Mancini-MarĂ¯e, A. A1 - Hodgins, Sheilagh A1 - Kononen, Mervi A1 - Boulay, L. A1 - Pihlajamaki, M. A1 - Soininen, Hilkka A1 - Stip, E. A1 - Tiihonen, Jari A1 - Aronen, Hannu J. SP - 97 EP - 102 VL - 91 IS - 1-3 N2 - The main goal of this functional Magnetic Resonance Imaging (fMRI) study was to verify the hypothesis that seriously violent persons with Sz and the co-morbid diagnoses of an Antisocial Personality Disorder (APD) and a Substance Use Disorder (Sz+APD+SUD) would present a different pattern of prefrontal functioning than seriously violent persons with Sz only. In support with the main hypothesis, frontal basal cortices were significantly less activated in persons with Sz+APD+SUD during the execution of a go/no-go task than in persons with Sz only and non-violent persons without a mental illness. In contrast, significantly higher activations in frontal motor, premotor and anterior cingulate regions were observed in the Sz+APD+SUD group than in the Sz-only group.

Language: en

LA - en SN - 0920-9964 UR - http://dx.doi.org/10.1016/j.schres.2006.12.014 ID - ref1 ER -