TY  - JOUR
PY  - 2021//
TI  - Brain basis of psychopathy in criminal offenders and general population
JO  - Cerebral cortex
A1  - Nummenmaa, Lauri
A1  - Lukkarinen, Lasse
A1  - Sun, Lihua
A1  - Putkinen, Vesa
A1  - Seppälä, Kerttu
A1  - Karjalainen, Tomi
A1  - Karlsson, Henry K.
A1  - Hudson, Matthew
A1  - Venetjoki, Niina
A1  - Salomaa, Marja
A1  - Rautio, Päivi
A1  - Hirvonen, Jussi
A1  - Lauerma, Hannu
A1  - Tiihonen, Jari
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Psychopathy is characterized by persistent antisocial behavior, impaired empathy, and egotistical traits. These traits vary also in normally functioning individuals. Here, we tested whether such antisocial personalities are associated with similar structural and neural alterations as those observed in criminal psychopathy. Subjects were 100 non-convicted well-functioning individuals, 19 violent male offenders, and 19 matched controls. Subjects underwent T1-weighted magnetic resonance imaging and viewed movie clips with varying violent content during functional magnetic resonance imaging. Psychopathic traits were evaluated with Levenson Self-Report Psychopathy Scale (controls) and Psychopathy Checklist-Revised (offenders). Psychopathic offenders had lower gray matter density (GMD) in orbitofrontal cortex and anterior insula. In the community sample, affective psychopathy traits were associated with lower GMD in the same areas. Viewing violence increased brain activity in periaqueductal grey matter, thalamus, somatosensory, premotor, and temporal cortices. Psychopathic offenders had increased responses to violence in thalamus and orbitofrontal, insular, and cingulate cortices. In the community sample, impulsivity-related psychopathy traits were positively associated with violence-elicited responses in similar areas. We conclude that brain characteristics underlying psychopathic spectrum in violent psychopathy are related to those observed in well-functioning individuals with asocial personality features.<p />  <p>Language: en</p>
LA  - en
SN  - 1047-3211
UR  - http://dx.doi.org/10.1093/cercor/bhab072
ID  - ref1
ER  -