TY  - JOUR
PY  - 2021//
TI  - Higher negative self-reference level in patients with personality disorders and suicide attempt(s) history during biological treatment for major depressive disorder: clinical implications
JO  - Frontiers in psychology
A1  - Bulteau, Samuel
A1  - Péré, Morgane
A1  - Blanchin, Myriam
A1  - Poulet, Emmanuel
A1  - Brunelin, Jerome
A1  - Sauvaget, Anne
A1  - Sébille, Véronique
SP  - e631614
EP  - e631614
VL  - 12
IS  - 
N2  - OBJECTIVE: The aim of the study was to identify clinical variables associated with changes in specific domains of self-reported depression during treatment by antidepressant and/or repetitive Transcranial Magnetic Stimulation (rTMS) in patients with Major Depressive Disorder (MDD). <br><br>METHODS: Data from a trial involving 170 patients with MDD receiving either venlafaxine, rTMS or both were re-analyzed. Depressive symptoms were assessed each week during the 2 to 6 weeks of treatment with the 13-item Beck Depression Inventory (BDI(13)). Associations between depression changes on BDI(13) domains (Negative Self-Reference, Sad Mood, and Performance Impairment), treatment arm, time, and clinical variables were tested in a mixed linear model. <br><br>RESULTS: A significant decrease of self-reported depressive symptoms was observed over time. The main characteristics associated with persistent higher depressive symptomatology on Negative Self-Reference domain of the BDI(13) were personality disorders (+2.1 points), a past history of suicide attempt(s) (+1.7 points), age under 65 years old (+1.5 points), and female sex (+1.1 points). <br><br>CONCLUSIONS: Early cognitive intervention targeting specifically negative self-referencing process could be considered during pharmacological or rTMS treatment for patients with personality disorders and past history of suicide attempt(s).<p />  <p>Language: en</p>
LA  - en
SN  - 1664-1078
UR  - http://dx.doi.org/10.3389/fpsyg.2021.631614
ID  - ref1
ER  -