TY  - JOUR
PY  - 2021//
TI  - Relationship between childhood physical abuse and clinical severity of treatment-resistant depression in a geriatric population
JO  - PLoS one
A1  - Yrondi, Antoine
A1  - Arbus, Christophe
A1  - Bennabi, Djamila
A1  - d'Amato, Thierry
A1  - Bellivier, Frank
A1  - Bougerol, Thierry
A1  - Camus, Vincent
A1  - Courtet, Philippe
A1  - Doumy, Olivier
A1  - Genty, Jean-Baptiste
A1  - Holtzmann, Jérôme
A1  - Horn, Mathilde
A1  - Lançon, Christophe
A1  - Leboyer, Marion
A1  - Llorca, Pierre-Michel
A1  - Maruani, Julia
A1  - Moirand, Remi
A1  - Molière, Fanny
A1  - Petrucci, Jean
A1  - Richieri, Raphaëlle
A1  - Samalin, Ludovic
A1  - Stephan, Florian
A1  - Vaiva, Guillaume
A1  - Walter, Michel
A1  - Haffen, Emmanuel
A1  - Aouizerate, Bruno
A1  - El-Hage, Wissam
SP  - e0250148
EP  - e0250148
VL  - 16
IS  - 4
N2  - INTRODUCTION: We assessed the correlation between childhood maltreatment (CM) and severity of depression in an elderly unipolar Treatment-Resistant Depression (TRD) sample. <br><br>METHODS: Patients were enrolled from a longitudinal cohort (FACE-DR) of the French Network of Expert TRD Centres. <br><br>RESULTS: Our sample included 96 patients (33% of the overall cohort) aged 60 years or above, with a mean age of 67.2 (SD = 5.7). The majority of the patients were female (62.5%). The Montgomery and Asberg Depression Rating Scale (MADRS) and Quick Inventory Depression Scale-Self Report (QIDS-SR) mean scores were high, 28.2 (SD = 7.49) [MADRS score range: 0-60; moderate severity≥20, high severity≥35] and 16.5 (SD = 4.94) [IDS-SR score range: 0-27; moderate severity≥11, high severity≥16], respectively. Mean self-esteem scores were 22.47 (SD = 6.26) [range 0-30]. In an age- and sex-adjusted model, we found a positive correlation between childhood trauma (CTQ scores) and depressive symptom severity [MADRS (β = 0.274; p = 0.07) and QIDS-SR (β = 0.302; p = 0.005) scores]. We detected a statistically significant correlation between physical abuse and depressive symptom severity [MADRS (β = 0.304; p = 0.03) and QIDS-SR (β = 0.362; p = 0.005) scores]. We did not observe any significant correlation between other types of trauma and depressive symptom severity. We showed that self-esteem (Rosenberg scale) mediated the effect of physical abuse (PA) on the intensity of depressive symptoms [MADRS: b = 0.318, 95% BCa C.I. [0.07, 0.62]; QIDS-SR: b = 0.177, 95% BCa C.I. [0.04, 0.37]]. Preacher & Kelly's Kappa Squared values of 19.1% (k2 = 0.191) and 16% (k2 = 0.16), respectively for the two scales, indicate a moderate effect. <br><br>CONCLUSION: To our knowledge, this is the first study conducted in a geriatric TRD population documenting an association between childhood trauma (mainly relating to PA) and the intensity of depressive symptoms.<p />  <p>Language: en</p>
LA  - en
SN  - 1932-6203
UR  - http://dx.doi.org/10.1371/journal.pone.0250148
ID  - ref1
ER  -