TY  - JOUR
PY  - 2021//
TI  - Recent sexual violence exposure is associated with immune biomarkers of HIV susceptibility in women
JO  - American journal of reproductive immunology (1989)
A1  - Aldous, Annette M.
A1  - Joy, Christopher
A1  - Daniels, Jason
A1  - Jais, Mariel
A1  - Simmens, Samuel J.
A1  - Magnus, Manya
A1  - Roberts, Afsoon
A1  - Connors, Kaleigh
A1  - Capozzi, Brendan
A1  - Mohamed, Hani
A1  - Juzumaite, Monika
A1  - DeVore, Heather
A1  - Moriarty, Theresa
A1  - Hatch Schultz, Catherine
A1  - Zumer, Maria
A1  - Simon, Gary
A1  - Ghosh, Mimi
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - PROBLEM: HIV/AIDS and sexual violence act synergistically and compromise women's health. Yet, immuno-biological mechanisms linking sexual violence and increased HIV susceptibility are poorly understood. <br><br>METHODS: We conducted a cross-sectional pilot study of HIV-uninfected women, comparing 13 women exposed to forced vaginal penetration within the past 12 weeks (Exposed) with 25 Non-Exposed women. ELISA assays were conducted for 49 biomarkers associated with HIV pathogenesis in plasma and cervicovaginal lavage (CVL). Differences between Exposed and Non-Exposed were analyzed by linear and logistic regression, using propensity score weighting to control for age, race, socioeconomic status, menstrual cycle and contraceptive use. <br><br>RESULTS: In CVL, Exposed women had significantly reduced chemokines MIP-3α (p < 0.01), MCP-1 (p < 0.01), and anti-HIV/wound-healing thrombospondin-1 (p = 0.03). They also had significantly increased inflammatory cytokine IL-1 α (p < 0.01) and were more likely to have detectable wound-healing PDGF (p = 0.02). In plasma, Exposed women had reduced chemokines MIP-3 α (p < 0.01) and IL-8 (p < 0.01), anti-inflammatory cytokine TGF-β (p = 0.02), anti-HIV/antimicrobial HBD-2 (p = 0.02) and wound-healing MMP-1 (p = 0.02). They also had increased thrombospondin-1 (p < 0.01) and Cathepsin B (p = 0.01). After applying the stringent method of false discovery rate adjustment, differences for IL-1 α (p = 0.05) and MCP-1 (p = 0.03) in CVL and MIP-3α (p = 0.03) in plasma remained significant. <br><br>CONCLUSIONS: We report systemic and mucosal immune dysregulation in women exposed to sexual violence. As these biomarkers have been associated with HIV pathogenesis, dysregulation may increase HIV susceptibility.<p />  <p>Language: en</p>
LA  - en
SN  - 1046-7408
UR  - http://dx.doi.org/10.1111/aji.13432
ID  - ref1
ER  -