TY  - JOUR
PY  - 2021//
TI  - Case report: colchicine toxicokinetic analysis in a poisoned child requiring extracorporeal life support
JO  - Frontiers in pediatrics
A1  - Pérez Marín, Maria
A1  - Prod'hom, Sylvain
A1  - de Villiers, Suzanne Francesca
A1  - Ferry, Thomas
A1  - Amiet, Vivianne
A1  - Natterer, Julia
A1  - Perez, Maria-Helena
A1  - Buclin, Thierry
A1  - Chtioui, Haithem
A1  - Longchamp, David
SP  - e658347
EP  - e658347
VL  - 9
IS  - 
N2  - Colchicine poisoning is associated with a poor prognosis, especially when leading to shock and multi-organ failure, and management is limited to supportive care, including multiple-dose activated charcoal. At therapeutic concentrations, colchicine elimination occurs mainly through hepatic metabolism and involves an enterohepatic circulation, with a small contribution of renal elimination (10-30%). Colchicine toxicokinetics is however rarely described, especially in children. We present the case of a 4-year-old patient who survived a severe iatrogenic colchicine intoxication with a dose of 0.5 mg/kg. She developed multi-organ failure and shock, but recovered after receiving aggressive resuscitation, including extracorporeal life support. Close monitoring of colchicine blood levels showed a plateau for 6 days, indicating impeded elimination resulting from liver failure. We observed no significant clearance from renal replacement therapy, nor activated charcoal, during this period. Extracorporeal life support may play a supportive role in the management of severe colchicine poisoning. However, extracorporeal techniques do not seem to improve colchicine elimination.<p />  <p>Language: en</p>
LA  - en
SN  - 2296-2360
UR  - http://dx.doi.org/10.3389/fped.2021.658347
ID  - ref1
ER  -