TY  - JOUR
PY  - 2021//
TI  - Formate test for bedside diagnosis of methanol poisoning
JO  - Basic and Clinical Pharmacology and Toxicology
A1  - Hovda, Knut Erik
A1  - Lao, Yvonne Elisabeth
A1  - Gadeholt, Gaut
A1  - Jacobsen, Dag
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Methanol poisoning kills thousands of people every year and remains a diagnostic challenge, especially where the resources are scarce, but also in high-income countries worldwide. We are in the course of developing a bedside strip to detect formate - the toxic metabolite of methanol. We hereby present the first clinical methanol case where formate was detected bedside from a drop of blood: The patient, a 61-year-old male, was admitted with a suspect methanol poisoning and severe metabolic acidosis. The test strip was positive after 3 minutes. Sodium bicarbonate (500mmol/L), fomepizole, dialysis, and folinic acid were given based on the positive test. The diagnosis was some hours later confirmed by GC-MS, showing a methanol concentration of 62 mmol/L (200 mg/dL) and a formate concentration of 19 mmol/L. Implementation of this technology into routine clinical use can potentially offer an opportunity for a step-change in the management of methanol poisoning.<p />  <p>Language: en</p>
LA  - en
SN  - 1742-7835
UR  - http://dx.doi.org/10.1111/bcpt.13597
ID  - ref1
ER  -