TY  - JOUR
PY  - 2021//
TI  - Abuse potential of synthetic cannabinoids: AM-1248, CB-13, and PB-22
JO  - Biomolecules and therapeutics (Seoul)
A1  - Hur, Kwang-Hyun
A1  - Ma, Shi-Xun
A1  - Lee, Bo-Ram
A1  - Ko, Yong-Hyun
A1  - Seo, Jee-Yeon
A1  - Ryu, Hye Won
A1  - Kim, Hye Jin
A1  - Yoon, Seolmin
A1  - Lee, Yong-Sup
A1  - Lee, Seok-Yong
A1  - Jang, Choon-Gon
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Currently, the expanding recreational use of synthetic cannabinoids (SCBs) threatens public health. SCBs produce psychoactive effects similar to those of tetrahydrocannabinol, the main component of cannabis, and additionally induce unexpected pharmacological side effects. SCBs are falsely advertised as legal and safe, but in reality, SCB abuse has been reported to cause acute intoxication and addictive disorders. However, because of the lack of scientific evidence to elucidate their dangerous pharmacological effects, SCBs are weakly regulated and continue to circulate in illegal drug markets. In the present study, the intravenous self-administration (IVSA) paradigm was used to evaluate the abuse potential of three SCBs (AM-1248, CB-13, and PB-22) in rats. All three SCBs maintained IVSA with a large number of infusions and active lever presses, demonstrating their reinforcing effects. The increase of active lever presses was particularly significant during the early IVSA sessions, indicating the reinforcementenhancing effects of the SCBs (AM-1248 and CB-13). The number of inactive lever presses was significantly higher in the SCB groups (AM-1248 and CB-13) than that in the vehicle group, indicating their impulsive effects. In summary, these results demonstrated that SCBs have distinct pharmacological properties and abuse potential.<p />  <p>Language: en</p>
LA  - en
SN  - 1976-9148
UR  - http://dx.doi.org/10.4062/biomolther.2020.212
ID  - ref1
ER  -