TY  - JOUR
PY  - 2021//
TI  - Alcohol-induced aggression in Drosophila
JO  - Addiction biology
A1  - Park, Annie
A1  - Tran, Tracy
A1  - Gutierrez, Linda
A1  - Stojanik, Christopher J.
A1  - Plyler, Julian
A1  - Thompson, Grace A.
A1  - Bohm, Rudolf A.
A1  - Scheuerman, Elizabeth A.
A1  - Smith, Dean P.
A1  - Atkinson, Nigel S.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Alcohol-induced aggression is a destructive and widespread phenomenon associated with violence and sexual assault. However, little is understood concerning its mechanistic origin. We have developed a Drosophila melanogaster model to genetically dissect and understand the phenomenon of sexually dimorphic alcohol-induced aggression. Males with blood alcohol levels of 0.04-mg/ml BAC were less aggressive than alcohol-naive males, but when the BAC had dropped to ~0.015 mg/ml, the alcohol-treated males showed an increase in aggression toward other males. This aggression-promoting treatment is referred to as the post-ethanol aggression (PEA) treatment. Females do not show increased aggression after the same treatment. PEA-treated males also spend less time courting and attempt to copulate earlier than alcohol-naive flies. PEA treatment induces expression of the FruM transcription factor (encoded by a male-specific transcript from the fruitless gene), whereas sedating doses of alcohol reduce FruM expression and reduce male aggression. Transgenic suppression of FruM induction also prevents alcohol-induced aggression. In male flies, alcohol-induced aggression is dependent on the male isoform of the fruitless transcription factor (FruM). Low-dose alcohol induces FruM expression and promotes aggression, whereas higher doses of alcohol suppress FruM and suppress aggression.<p />  <p>Language: en</p>
LA  - en
SN  - 1355-6215
UR  - http://dx.doi.org/10.1111/adb.13045
ID  - ref1
ER  -