TY  - JOUR
PY  - 2021//
TI  - Mortality in substance-induced psychosis: a register-based national cohort study
JO  - Addiction
A1  - Nordentoft, Merete
A1  - Erlangsen, Annette
A1  - Starzer, Marie
A1  - Madsen, Trine
A1  - Hjorthøj, Carsten
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - AIMS: We aimed to analyze whether people with substance-induced psychosis (SIP), both those who convert and do not convert to schizophrenia, have higher all-cause and cause-specific mortality when compared to the general population. <br><br>DESIGN: Prospective cohort study. SETTING: Nationwide Danish registers. PARTICIPANTS/CASES: We included all people born in Denmark, living in Denmark on their 15(th) birthday, and aged 15 or more during the study period from January 1(st) , 1994, and August 10(th) , 2017. MEASUREMENTS: Exposure was categorized as: 1) Neither SIP nor schizophrenia; 2) SIP without preceding schizophrenia; 3) SIP converted to schizophrenia; 4) Schizophrenia without preceding SIP. Any SIP and substance-specific SIPS were examined regarding all-cause and cause-specific mortality. <br><br>FINDINGS: The study included a total of 5,619,691 individuals. Compared to people with neither schizophrenia nor SIP, people with SIP without preceding schizophrenia had an increased risk of dying (hazard ratio (HR)=6.23, 95% confidence interval (CI) 5.96-6.50), as had those with SIP converting to schizophrenia (HR=9.77, 95% CI 8.84-10.79) and those with only schizophrenia (HR=3.07, 95% CI 3.03-3.13). A similar pattern, albeit with higher HRs, was observed for suicides and accidental deaths. Other cause-specific-mortality groups also generally showed the same pattern, as did types of individual substances. <br><br>CONCLUSIONS: SIP was strongly associated with an increased risk of both all-cause and cause-specific mortality, even among cases who did not convert to schizophrenia. This provides a strong rationale for monitoring people with previous diagnosis of SIP and developing and implementing interventions to reduce this excess mortality.<p />  <p>Language: en</p>
LA  - en
SN  - 0965-2140
UR  - http://dx.doi.org/10.1111/add.15598
ID  - ref1
ER  -