TY - JOUR PY - 2021// TI - Mining of consumer product ingredient and purchasing data to identify potential chemical coexposures JO - Environmental health perspectives A1 - Stanfield, Zachary A1 - Addington, Cody K. A1 - Dionisio, Kathie L. A1 - Lyons, David A1 - Tornero-Velez, Rogelio A1 - Phillips, Katherine A. A1 - Buckley, Timothy J. A1 - Isaacs, Kristin K. SP - 67006 EP - 67006 VL - 129 IS - 6 N2 - BACKGROUND: Chemicals in consumer products are a major contributor to human chemical coexposures. Consumers purchase and use a wide variety of products containing potentially thousands of chemicals. There is a need to identify potential real-world chemical coexposures to prioritize in vitro toxicity screening. However, due to the vast number of potential chemical combinations, this identification has been a major challenge.

OBJECTIVES: We aimed to develop and implement a data-driven procedure for identifying prevalent chemical combinations to which humans are exposed through purchase and use of consumer products.

METHODS: We applied frequent itemset mining to an integrated data set linking consumer product chemical ingredient data with product purchasing data from 60,000 households to identify chemical combinations resulting from co-use of consumer products.

RESULTS: We identified co-occurrence patterns of chemicals over all households as well as those specific to demographic groups based on race/ethnicity, income, education, and family composition. We also identified chemicals with the highest potential for aggregate exposure by identifying chemicals occurring in multiple products used by the same household. Last, a case study of chemicals active in estrogen and androgen receptor in silico models revealed priority chemical combinations co-targeting receptors involved in important biological signaling pathways.

DISCUSSION: Integration and comprehensive analysis of household purchasing data and product-chemical information provided a means to assess human near-field exposure and inform selection of chemical combinations for high-throughput screening in in vitro assays. https://doi.org/10.1289/EHP8610.

Language: en

LA - en SN - 0091-6765 UR - http://dx.doi.org/10.1289/EHP8610 ID - ref1 ER -