TY  - JOUR
PY  - 2021//
TI  - European guideline and expert statements on the management of narcolepsy in adults and children
JO  - European journal of neurology
A1  - Bassetti, Claudio L. A.
A1  - Kallweit, Ulf
A1  - Vignatelli, Luca
A1  - Plazzi, Giuseppe
A1  - Lecendreux, Michel
A1  - Baldin, Elisa
A1  - Dolenc-Groselj, Leja
A1  - Jennum, Poul
A1  - Khatami, Ramin
A1  - Manconi, Mauro
A1  - Mayer, Geert
A1  - Partinen, Markku
A1  - Pollmächer, Thomas
A1  - Reading, Paul
A1  - Santamaria, Joan
A1  - Sonka, Karel
A1  - Dauvilliers, Yves
A1  - Lammers, Gert J.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND AND AIM: Narcolepsy is an uncommon hypothalamic disorder of presumed autoimmune origin that usually requires lifelong treatment. This paper aims to provide evidence-based guidelines for the management of narcolepsy in both adults and children. <br><br>METHODS: The European Academy of Neurology (EAN), European Sleep Research Society (ESRS) and European Narcolepsy Network (EU-NN) nominated a task force of 18 narcolepsy specialists. According to the EAN recommendations, 10 relevant clinical questions were formulated in PICO format. Following a systematic review of the literature (performed in Fall 2018 and updated in July 2020) recommendations were developed according to the GRADE approach. <br><br>RESULTS: A total of 10,247 references were evaluated, 308 studies were assessed and 155 finally included. The main recommendations can be summarized as follows: (i) excessive daytime sleepiness in adults-scheduled naps, modafinil, pitolisant, sodium oxybate (SXB), solriamfetol (all strong), methylphenidate, amphetamine derivates (both weak); (ii) cataplexy in adults-SXB, venlafaxine, clomipramine (all strong) and pitolisant (weak); (iii) excessive daytime sleepiness in children-scheduled naps, SXB (both strong), modafinil, methylphenidate, pitolisant, amphetamine derivates (all weak); (iv) cataplexy in children-SXB (strong), antidepressants (weak). Treatment choices should be tailored to each patient's symptoms, comorbidities, tolerance and risk of potential drug interactions. <br><br>CONCLUSION: The management of narcolepsy involves non-pharmacological and pharmacological approaches with an increasing number of symptomatic treatment options for adults and children that have been studied in some detail.<p />  <p>Language: en</p>
LA  - en
SN  - 1351-5101
UR  - http://dx.doi.org/10.1111/ene.14888
ID  - ref1
ER  -