TY  - JOUR
PY  - 2021//
TI  - A neurobiological link between transportation noise exposure and metabolic disease in humans
JO  - Psychoneuroendocrinology
A1  - Osborne, Michael T.
A1  - Naddaf, Nicki
A1  - Abohashem, Shady
A1  - Radfar, Azar
A1  - Ghoneem, Ahmed
A1  - Dar, Tawseef
A1  - Wang, Ying
A1  - Patrich, Tomas
A1  - Oberfeld, Blake
A1  - Tung, Brian
A1  - Pitman, Roger K.
A1  - Mehta, Nehal N.
A1  - Shin, Lisa M.
A1  - Lo, Janet
A1  - Rajagopalan, Sanjay
A1  - Koenen, Karestan C.
A1  - Grinspoon, Steven K.
A1  - Fayad, Zahi A.
A1  - Tawakol, Ahmed
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Chronic transportation noise exposure associates with cardiovascular events through a link involving heightened stress-associated neurobiological activity (as amygdalar metabolic activity, AmygA) on (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT). Increased AmygA also associates with greater visceral adipose tissue (VAT) and type 2 diabetes mellitus (DM). While relationships between noise exposure and VAT and DM have been reported, the underlying mechanisms remain incompletely understood. We tested whether: (1) transportation noise exposure associates with greater (a) baseline and gains in VAT and (b) DM risk, and (2) heightened AmygA partially mediates the link between noise exposure and these metabolic diseases. <br><br>METHODS: VAT was measured in a retrospective cohort (N = 403) who underwent clinical (18)F-FDG-PET/CT. AmygA was measured in those with brain imaging (N = 238). Follow-up VAT was remeasured on available imaging (N = 67). Among individuals (N = 224) without baseline DM, incident DM was adjudicated over 2 years from clinical records. Noise (24-h average) was modeled at each individual's home address. Linear regression, survival, and mediation analyses were employed. <br><br>RESULTS: Higher noise exposure (upper tertile vs. others) associated with greater: baseline VAT (standardized β [95% confidence interval (CI)]= 0.230 [0.021, 0.438], p = 0.031), gains in VAT (0.686 [0.185, 1.187], p = 0.008 adjusted for baseline VAT), and DM (hazard ratio [95% CI]=2.429 [1.031, 5.719], p = 0.042). The paths of: ↑noise exposure→↑AmygA→↑baseline VAT and ↑noise exposure→↑AmygA→↑subsequent DM were significant (p < 0.05). <br><br>CONCLUSIONS: Increased transportation noise exposure associates with greater VAT and DM. This relationship is partially mediated by stress-associated neurobiological activity. These findings suggest altered neurobiology contributes to noise exposure's link to metabolic diseases.<p />  <p>Language: en</p>
LA  - en
SN  - 0306-4530
UR  - http://dx.doi.org/10.1016/j.psyneuen.2021.105331
ID  - ref1
ER  -